An axis-specific mitral annuloplasty ring eliminates mitral regurgitation allowing mitral annular motion in an ovine model
The axis-specific mitral annuloplasty ring we designed demonstrates excellent capability to repair mitral regurgitation while facilitating dynamic mitral annular motion. This ring has tremendous potential for clinical translatability, representing a promising surgical solution for mitral regurgitation.
Authors
- Sidarth Ethiraj (ORCID: https://orcid.org/0000-0001-6943-1202)
- Mateo Marin‐Cuartas (ORCID: https://orcid.org/0000-0003-1000-4710)
- Sabrina K. Walsh (ORCID: https://orcid.org/0000-0002-2041-7693)
- Shreya Anilkumar
- Haley J. Lucian (ORCID: https://orcid.org/0000-0001-6834-7295)
- Sarah Madira
- Shin Yajima (ORCID: https://orcid.org/0000-0001-5058-0267)
- Yasuhiro Shudo (ORCID: https://orcid.org/0000-0002-4545-1273)
- Ok Kim (ORCID: https://orcid.org/0000-0001-5999-7958)
- Jack Mulligan
- Annabel M. Imbrie-Moore (ORCID: https://orcid.org/0000-0002-0857-0388)
- Y. Joseph Woo (ORCID: https://orcid.org/0000-0002-2506-492X)
- Yuanjia Zhu (ORCID: https://orcid.org/0000-0001-5642-9883)
- Daniel B. Ennis (ORCID: https://orcid.org/0000-0001-7435-1311)
- Yuko Tada (ORCID: https://orcid.org/0000-0003-1410-9894)
- Matthew H. Park (ORCID: https://orcid.org/0000-0003-1191-8813)
- Vicky Y. Wang (ORCID: https://orcid.org/0000-0003-0895-3132)
- Robert J. Wilkerson (ORCID: https://orcid.org/0000-0002-9983-2100)
- Kimberly Morris
- Tyler E. Cork (ORCID: https://orcid.org/0000-0001-5759-5322)
- Danielle M. Mullis (ORCID: https://orcid.org/0000-0003-4743-0000)
- Tsuyoshi Ueyama
- Chris Huynh
- Nicholas A. Tran
- Matthew Leipzig
- Sam W. Baker
- Hui Wang (ORCID: https://orcid.org/0009-0005-8063-9051)
Institutions
- Cardiovascular Institute of the South (US)
- Leipzig Heart Institute (DE)
- Stanford Medicine (US)
- Stanford University (US)
- The University of Osaka (JP)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-02-12
- DOI
- https://doi.org/10.1038/s43856-025-00753-6
- Citations
- 1
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- National Science Foundation
- Thoracic Surgery Foundation
- National Institutes of Health
- Department of Mechanical Engineering, Stanford University