Piezoelectric‐Enhanced Nanocatalysts Trigger Neutrophil N1 Polarization against Bacterial Biofilm by Disrupting Redox Homeostasis (Adv. Mater. 6/2025)
Biofilm Eradication In article number 2409633, Min Ge, Chuang Yang, Han Lin, Jianlin Shi, and co-workers developed a physical and chemical barrier breakthrough strategy for biofilms via redox homeostasis manipulation. The nanosystem can enhance the attack of ROS via exogenous stimulation while providing interference with endogenous H2S synthase to reduce the resistance of reducing species, which together lead to severe structural damage in biofilms. In addition, oxidative stress mediates N1 polarization of neutrophils, leading to immunobactericidal effects.
Authors
- Jiawei Mei
- Wanbo Zhu (ORCID: https://orcid.org/0000-0003-3457-3432)
- Chuang Yang (ORCID: https://orcid.org/0000-0001-7277-4417)
- Min Ge (ORCID: https://orcid.org/0000-0001-6106-2721)
- Tingting Hu (ORCID: https://orcid.org/0000-0003-1785-657X)
- Lin Han (ORCID: https://orcid.org/0000-0002-0137-5176)
- Jianlin Shi (ORCID: https://orcid.org/0000-0001-8790-195X)
Institutions
- Tongji University (CN)
- University of Science and Technology of China (CN)
- Shanghai Jiao Tong University (CN)
- Chinese Academy of Sciences (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Shanghai Tenth People's Hospital (CN)
- Shanghai Sixth People's Hospital (CN)
- Shanghai Institute of Ceramics (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Advanced Materials
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/adma.202570050
- Citations
- 1
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.67