Chronic optogenetic stimulation of dentate gyrus granule cells in mouse organotypic slice cultures synaptically drives mossy cell degeneration
The role of mossy cells in the context of epileptic seizures has been a controversial topic of discussion. The presented in vitro model allows the study of mossy cell vulnerability on a single-cell level and provides the first evidence for changes in synaptic activity after stimulation. This model will facilitate our mechanistic understanding of temporal lobe epilepsy, providing a foundation for novel therapeutic interventions aimed at preserving mossy cell function in epilepsy patients.
Authors
- Thomas Deller (ORCID: https://orcid.org/0000-0002-3931-2947)
- Alexander Drakew
- Rebecca Schneider (ORCID: https://orcid.org/0000-0002-8496-4178)
- Tassilo Jungenitz (ORCID: https://orcid.org/0000-0001-7291-8548)
- Jochen Roeper (ORCID: https://orcid.org/0000-0003-2145-8742)
- Carolin Christina Koretz (ORCID: https://orcid.org/0009-0009-6405-5514)
Institutions
- Goethe University Frankfurt (DE)
Publication Details
- Journal
- Epilepsia
- Published
- 2025-02-12
- DOI
- https://doi.org/10.1111/epi.18314
- Primary Topic
- Photoreceptor and optogenetics research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- International Max Planck Research School for Environmental, Cellular and Molecular Microbiology
- International Max Planck Research School for Advanced Methods in Process and Systems Engineering