Metabolomic Characteristics of Aqueous Humor in Wet Age-Related Macular Degeneration and the Impact of Anti-VEGF Treatment
There were noticeable alterations in the aqueous humor of patients with wAMD involving many metabolites that are associated with ABC transporters, glycerophospholipid metabolism, and the mammalian target of rapamycin signaling pathway. It is possible that δ-valerolactam can be applied as a biomarker in wAMD.
Authors
- Shian Zhang (ORCID: https://orcid.org/0000-0003-3168-4962)
- Jianbo Mao (ORCID: https://orcid.org/0000-0002-5437-7749)
- Jiaguo Yu (ORCID: https://orcid.org/0000-0002-0612-8633)
- Yanli Zhang (ORCID: https://orcid.org/0000-0002-8942-5325)
- Xiaoya Zhang (ORCID: https://orcid.org/0000-0002-5425-8547)
- Yijing Chen (ORCID: https://orcid.org/0000-0003-1633-127X)
- Lijun Shen (ORCID: https://orcid.org/0009-0009-7003-9545)
- Yubo Wu (ORCID: https://orcid.org/0009-0006-3908-7512)
Institutions
- Wenzhou Medical University (CN)
- Zhejiang Lab (CN)
- Zhejiang Provincial People's Hospital (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-02-12
- DOI
- https://doi.org/10.1167/iovs.66.2.37
- Citations
- 2
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.41
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province