PI3K pathway activation in severe asthma is linked to steroid insensitivity and adverse outcomes
Patients with severe asthma demonstrate reduced steroid sensitivity, which results in unfavorable clinical outcomes. Conversely, inhibition of the PI3K pathway significantly improves steroid sensitivity.
Authors
- Keita Hirai (ORCID: https://orcid.org/0000-0001-8027-3508)
- Kunihiko Itoh (ORCID: https://orcid.org/0000-0003-4436-0529)
- Sekiko Uehara
- Toshihiro Shirai
- Taisuke Akamatsu
Institutions
- Shinshu University (JP)
- University of Shizuoka (JP)
- Shinshu University Hospital (JP)
- Shizuoka General Hospital (JP)
Publication Details
- Journal
- Journal of Allergy and Clinical Immunology Global
- Published
- 2025-02-12
- DOI
- https://doi.org/10.1016/j.jacig.2025.100439
- Citations
- 4
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 4.66
Funders
- Pharmaceutical Society of Japan
- Japan Society for the Promotion of Science