Immunohistochemical method of megakaryocytic lineage staining in bone marrow biopsy specimens as an additional pathomorphological differential diagnostic sign of primary myelofibrosis and essential thrombocythemia
The revealed statistically significant differences in quantitative and geometric characteristics of megakaryocytes allowed to calculate differential threshold values of characteristics of megakaryocytic lineage of myeloid tissue in diagnostic trepanobioptates of bone marrow from patients with primary myelofibrosis and essential thrombocythemia. Counting the number of CD42b-positive megakaryocytes in one field of view at a magnification of 400 times was proposed as an additional pathomorphological differential-diagnostic sign.
Authors
- Yuri A. Krivolapov (ORCID: https://orcid.org/0000-0002-9872-0326)
- Zakhar P. Asaulenko (ORCID: https://orcid.org/0000-0001-7062-065X)
Institutions
- City Hospital No. 40 (RU)
- North-Western State Medical University named after I.I. Mechnikov (RU)
Publication Details
- Journal
- Russian Journal of Archive of Pathology
- Published
- 2025-02-12
- DOI
- https://doi.org/10.17116/patol20258701122
- Primary Topic
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00