Blocking S1P4 signaling attenuates brain injury in mice with ischemic stroke
Using a functional S1P<sub>4</sub> antagonist (NXC736) and a genetic tool for S1P<sub>4</sub> knockdown, we identified S1P<sub>4</sub> as a novel pathogenic factor in ischemic stroke.
Authors
- Joo‐Youn Lee (ORCID: https://orcid.org/0000-0001-5685-9875)
- Arjun Sapkota
- Seungbae Park
- Hyun-kyung Cho (ORCID: https://orcid.org/0000-0001-5631-5077)
- Bong Yong Lee
- Bhakta Prasad Gaire (ORCID: https://orcid.org/0000-0002-9738-6493)
- Nikita Basnet
- Chaemin Lim (ORCID: https://orcid.org/0000-0001-9029-7984)
- Donghee Kim (ORCID: https://orcid.org/0000-0001-8773-6528)
- Seunghee Lee (ORCID: https://orcid.org/0000-0001-5483-0016)
- Sanghee Kim (ORCID: https://orcid.org/0000-0001-9125-9541)
- Ji Woong Choi (ORCID: https://orcid.org/0000-0003-1850-4189)
- Jae Hui Been
Institutions
- Gachon University (KR)
- Seoul National University (KR)
- Nexen (Canada) (CA)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-02-12
- DOI
- https://doi.org/10.1016/j.jare.2025.02.012
- Citations
- 4
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- National Research Foundation
- Gachon University