Low-Energy Electron Irradiation Inactivates Viruses in Serum and Maintains Growth-Promoting Properties in Cell Culture
LEEI is able to inactivate viral contaminants in serum and offers significant advantages over gamma irradiation, as no large amounts of radioactivity are generated, on-site irradiation is possible, and space requirements are reduced due to fewer protective measures. These advantages allow the technology to be used in a GMP-compliant irradiation process.
Authors
- Philipp Becker (ORCID: https://orcid.org/0000-0001-6901-6527)
- Gustavo R. Makert
- Sebastian Ulbert (ORCID: https://orcid.org/0000-0001-5910-3643)
- Jasmin Fertey (ORCID: https://orcid.org/0000-0001-5424-3807)
- Julia Finkensieper
Institutions
- Fraunhofer Institute for Cell Therapy and Immunology (DE)
Publication Details
- Journal
- Applied Biosafety
- Published
- 2025-02-12
- DOI
- https://doi.org/10.1089/apb.2024.0031
- Primary Topic
- Electromagnetic Fields and Biological Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00