Geliboluols A–D: Kaurane-Type Diterpenoids from the Marine-Derived Rare Actinomycete Actinomadura geliboluensis
Four new kaurane-type diterpenoids, geliboluols A-D (<b>1</b>-<b>4</b>), along with one known analog (<b>5</b>), were isolated from the culture broth of the marine-derived rare actinomycete <i>Actinomadura geliboluensis</i>. The structures of compounds <b>1</b>-<b>4</b> were determined by spectroscopic analysis (HR-ESIMS, 1D, and 2D NMR), the MPA method, and by comparing their optical rotation values with those in the literature. The new compounds were evaluated for their cytotoxicity against seven blood cancer cell lines by a CellTiter-Glo (CTG) assay and six solid cancer cell lines by a sulforhodamine B (SRB) assay. Among the new compounds, compound <b>4</b> exhibited moderate cytotoxic activity against some blood cancer cell lines, with GI<sub>50</sub> values ranging from 2.59 to 19.64 µM, and against solid cancer cell lines with GI<sub>50</sub> values ranging from 4.34 to 7.23 µM.
Authors
- Hee Jae Shin (ORCID: https://orcid.org/0000-0002-5952-5325)
- Hwa‐Sun Lee (ORCID: https://orcid.org/0000-0003-0435-5688)
- Jeong-Wook Yang
- Jong Soon Kang (ORCID: https://orcid.org/0000-0001-7698-0162)
- Chang-Su Heo
- Min Ah Lee
- Chang Hwan Kim
Institutions
- Korea Institute of Ocean Science and Technology (KR)
- Korea Research Institute of Bioscience and Biotechnology (KR)
- Korea University of Science and Technology (KR)
- Pukyong National University (KR)
Publication Details
- Journal
- Marine Drugs
- Published
- 2025-02-10
- DOI
- https://doi.org/10.3390/md23020078
- Citations
- 2
- Primary Topic
- Marine Sponges and Natural Products
- Type
- article
- Field-Weighted Citation Impact
- 2.47
Funders
- Ministry of Oceans and Fisheries
- Korea Institute of Ocean Science and Technology