Monitoring the neurological complications of chimeric antigen receptor (CAR) T-cell therapy in patients with sensory and physical impairments and non-native-speaking backgrounds using modified immune effector cell-associated encephalopathy (ICE) scor
These cases highlight the need for flexible and patient-tailored strategies and the importance of collaboration between multidisciplinary teams and patients' families/caregivers when monitoring patients for ICANS after CAR T-cell therapy.
Authors
- Miriam Wronski (ORCID: https://orcid.org/0000-0003-4888-7707)
- Andrew Spencer (ORCID: https://orcid.org/0000-0002-0531-7424)
- Shu Min Wong (ORCID: https://orcid.org/0000-0002-2520-6887)
- Charles Benjamin Malpas (ORCID: https://orcid.org/0000-0003-0534-3718)
- Shaun Fleming (ORCID: https://orcid.org/0000-0002-9734-5616)
- Terence John O'Brien (ORCID: https://orcid.org/0000-0002-7198-8621)
- Robb Wesselingh (ORCID: https://orcid.org/0000-0002-5898-3287)
- Constantine Si Lun Tam (ORCID: https://orcid.org/0000-0002-9759-5017)
- Mastura Monif (ORCID: https://orcid.org/0000-0001-6404-9768)
- Christina Kazzi (ORCID: https://orcid.org/0000-0001-6737-5489)
- Cassandra Abbott
- Nabil Seery (ORCID: https://orcid.org/0000-0001-6446-868X)
- Tracie Tan
- T. Ian Simpson (ORCID: https://orcid.org/0000-0003-0495-7187)
- Rubina Alpitsis
- Kevin Ko
- Shafqat Inam
Institutions
- The Royal Melbourne Hospital (AU)
- The University of Melbourne (AU)
- The Alfred Hospital (AU)
- Australian Centre for HIV and Hepatitis Virology Research (AU)
- Alfred Health (AU)
- Monash University (AU)
Publication Details
- Journal
- BMJ Neurology Open
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1136/bmjno-2024-000927
- Citations
- 1
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Eli Lilly and Company
- AstraZeneca
- Gilead Sciences
- Biogen
- Royal Melbourne Hospital Neuroscience Foundation
- LivaNova
- Australian Government
- BeiGene
- Multiple Sclerosis Australia
- University of Melbourne
- Eisai
- Dementia Australia
- Medical Research Council
- National Health and Medical Research Council
- National Institute of Neurological Disorders and Stroke
- UCB Pharma