CD56<sup>bright</sup> cytokine-induced memory-like NK cells and NK-cell engagers synergize against non-small cell lung cancer cancer-stem cells
Our study discloses for the first time the therapeutic potential of CIML-NK cells in controlling CSCs and metastatic spread, highlighting the role of the CD56<sup>bright</sup> subset expansion and 1615133 TriKE for optimizing CIML-NK-based therapies against metastatic tumors.
Authors
- Fabrizio Loiacono (ORCID: https://orcid.org/0000-0001-9370-8910)
- Giulia Bertolini (ORCID: https://orcid.org/0000-0002-8495-4594)
- Claudia Cantoni (ORCID: https://orcid.org/0000-0001-6471-1424)
- Stefano Persano (ORCID: https://orcid.org/0000-0002-7013-5977)
- Daniel A. Vallera (ORCID: https://orcid.org/0000-0003-4587-3238)
- Maria Cristina Mingari (ORCID: https://orcid.org/0000-0001-6998-5459)
- Simona Sivori (ORCID: https://orcid.org/0000-0003-1279-1172)
- Paola Orecchia (ORCID: https://orcid.org/0000-0003-0556-9784)
- Federica Facchinetti
- Monica Parodi (ORCID: https://orcid.org/0000-0001-9606-2190)
- Martin Felices (ORCID: https://orcid.org/0000-0002-5945-0634)
- Riccardo Ferracini (ORCID: https://orcid.org/0000-0001-7654-0327)
- Luca Roz (ORCID: https://orcid.org/0000-0001-5817-7149)
- Massimo Vitale (ORCID: https://orcid.org/0000-0001-5372-7885)
- Manuela Lopez
- Ann Gebo (ORCID: https://orcid.org/0009-0005-7860-5020)
- Marco Gentili
- Marco Pravetoni
- Josephine Maus-Conn
Institutions
- University of Minnesota (US)
- University of Washington (US)
- Istituto Giannina Gaslini (IT)
- Ospedale Koelliker (IT)
- Ospedale Policlinico San Martino (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- University of Genoa (IT)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1136/jitc-2024-010205
- Citations
- 10
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 7.97
Funders
- University of Minnesota
- Ministero della Salute
- Associazione Italiana per la Ricerca sul Cancro
- Regione Lombardia
- Fondazione Regionale per la Ricerca Biomedica