Acetyltransferase NAT10 inhibits T-cell immunity and promotes nasopharyngeal carcinoma progression through DDX5/HMGB1 axis
Our study elucidates the mechanism by which the <i>NAT10/DDX5/HMGB1</i> axis promotes the immunosuppression of NPC by promoting T-cell dysfunction. In addition, NAT10 knockdown can enhance anti-PD-1 treatment sensitivity as a combination therapy for NPC.
Authors
- Rui Wu (ORCID: https://orcid.org/0000-0001-7910-6614)
- Yi Xu (ORCID: https://orcid.org/0000-0003-1235-3068)
- Haimeng Yin (ORCID: https://orcid.org/0000-0002-4275-0956)
- Haijing Xie
- Bo You (ORCID: https://orcid.org/0000-0002-3602-5264)
- Yumo Han
- Weihong Jiang
- Siyu Zhang (ORCID: https://orcid.org/0000-0001-9355-1650)
- Kaiwen Zhang (ORCID: https://orcid.org/0009-0003-8126-383X)
- Si Pan (ORCID: https://orcid.org/0000-0003-4866-2639)
Institutions
- Central South University (CN)
- Nantong University (CN)
- Affiliated Hospital of Nantong University (CN)
- National Clinical Research (US)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1136/jitc-2024-010301
- Citations
- 15
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 12.09
Funders
- National Natural Science Foundation of China