Self-Adaptive Weight Embedded Lightweight Network Using Semi-Supervised Learning for Low-Dose CT Image Denoising

Low-dose computed tomography (LDCT) denoising methods based on supervised learning with labeled simulation data have made significant progress. However, these methods usually struggle to directly process unlabeled LDCT images due to inherent biases. While unsupervised methods have been explored to utilize unlabeled LDCT images, they typically involve complex network structures with limited denoising performance. To address these issues, we propose a self-adaptive weight embedded lightweight semi-supervised network (SWELNet) for unlabeled LDCT image denoising, which integrates supervised and unsupervised learning in a lightweight architecture. Unlike other semi-supervised algorithms that only consider the correlations between labeled simulation data and unlabeled data, the proposed SWELNet not only takes into account correlations but also the differences between data. There are three modules in the proposed network, respectively, for feature extraction, refinement and self-adaptive weight. Specially, the multiscale convolution feature extraction module (MCFEM) and recursive module (RECM) extract and refine common representations from labeled simulation and unlabeled data with the well-designed. After that, the softmax feature fusion module (SFFM) with self-adaptive weighted learning for forming different feature spaces for two types of data. Extensive experiments using one simulation and two unlabeled datasets demonstrate that the proposed SWELNet outperforms several state-of-the-art baseline network methods in terms of robustness and generalization, as well as inference efficiency. The code is available at <uri xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">https://github.com/nightastars/SWELNet-main.git</uri>.