Upregulated LIMD1 alleviates pressure overload-induced cardiac hypertrophy via inhibits YAP1/AKT/GSK3β signaling
In summary, this study is the first to demonstrate the protective effects of LIMD1 against TAC-induced pathological cardiac remodeling. These effects are attributed to the inhibition of the YAP1/AKT/GSK3β signaling pathway.
Authors
- Yingmei Zhong
- Fengwen Xie
- Ye Zhang (ORCID: https://orcid.org/0009-0000-4883-8097)
- Quan Xu (ORCID: https://orcid.org/0000-0001-9604-7601)
- Bin Yuan (ORCID: https://orcid.org/0009-0009-3177-5478)
- L. Chen
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Jiangxi Provincial People's Hospital (CN)
- First Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-02-12
- DOI
- https://doi.org/10.1371/journal.pone.0316149
- Citations
- 1
- Primary Topic
- Cardiovascular Effects of Exercise
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Health Commission of Jiangxi Province