RVOT Stenting and Trametinib in an Infant With Noonan Syndrome, Pulmonary Stenosis, and Hypertrophic Cardiomyopathy

Right ventricular outflow tract stenting is a viable mode of palliation in infants with Noonan syndrome and pulmonary valve stenosis who are not ideal surgical candidates. An increasing number of case reports are demonstrating the efficacy of MEK inhibition as an effective tool for treatment of Noonan syndrome-associated hypertrophic cardiomyopathy.