Confirmatory Biopsy Outcomes in Patients with Grade Group 2 Prostate Cancer: Implications for Early Management
For patients with grade group (GG) 2 prostate cancer, we found that the amount of Gleason pattern 4 cancer in the initial biopsy, PSA (prostate-specific antigen) density, and MRI (magnetic resonance imaging) findings help to identify men who are likely to be downgraded to less aggressive GG 1 cancer or no cancer at all on a repeat confirmatory biopsy. We assessed these predictors in a group of patients with similar characteristics who underwent immediate surgery, and found that approximately two-thirds would benefit from a confirmatory biopsy.
Authors
- Samson W. Fine (ORCID: https://orcid.org/0000-0002-4322-3736)
- Andrew Julian Vickers (ORCID: https://orcid.org/0000-0003-1525-6503)
- Emily Vertosick (ORCID: https://orcid.org/0000-0001-6948-9850)
- Riccardo Leni (ORCID: https://orcid.org/0000-0003-0779-0984)
- Oğuz Akın (ORCID: https://orcid.org/0000-0002-2041-6199)
- Behfar Ehdaie
- Sigrid Carlsson (ORCID: https://orcid.org/0000-0003-3553-5710)
- Nicole Liso
- Francesco Montorsi
- James A. Eastham
- Alberto Briganti
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- Vita-Salute San Raffaele University (IT)
- Lund University (SE)
- University of Gothenburg (SE)
Publication Details
- Journal
- European Urology Open Science
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1016/j.euros.2025.01.012
- Citations
- 3
- Primary Topic
- Prostate Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.56
Funders
- National Cancer Institute