Dose-Dependent Relationship Between Long-Term Metformin Use and the Risk of Diabetic Retinopathy: A Population-Based Cohort Study
Patients with DM treated with a lower cumulative dosage of metformin showed beneficial effects that were associated with a lower risk of diabetic retinopathy. In contrast, a higher intensity of metformin use had a greater risk of diabetic retinopathy.
Authors
- Yu-Ching Li
- Chien‐Ying Lee (ORCID: https://orcid.org/0000-0001-8159-4645)
- Yih Yang
- Shuo‐Yan Gau (ORCID: https://orcid.org/0000-0001-8897-5635)
- Kuang‐Hua Huang (ORCID: https://orcid.org/0000-0003-4351-6202)
- Tung‐Han Tsai
Institutions
- China Medical University (TW)
- E-Da Hospital (TW)
- Chung Shan Medical University Hospital (TW)
- Chung Shan Medical University (TW)
- I-Shou University (TW)
Publication Details
- Journal
- Clinical Drug Investigation
- Published
- 2025-02-12
- DOI
- https://doi.org/10.1007/s40261-025-01421-2
- Citations
- 3
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 3.88
Funders
- China Medical University
- Chung Shan Medical University
- China Medical University, Taiwan
- Health and Welfare Data Science Center