Causal roles of immune cells and metabolites in chronic pancreatitis: a mendelian randomization study
Our findings provide valuable insights into the genetic underpinnings of CP, highlighting the role of immune cells and plasma metabolites in its pathogenesis. The mediation analysis further suggests that the presence of CD25 on IgD-CD38-B cells may facilitate CP development through the elevation of cholesterol levels. These results not only deepen our understanding of CP but also suggest potential biological targets for therapeutic intervention. Future clinical research should focus on these mediators to develop more effective treatment strategies for CP.
Authors
- Chao Zhang (ORCID: https://orcid.org/0000-0002-4222-9968)
- Chengli Wen (ORCID: https://orcid.org/0000-0001-8956-8898)
- Yu Yuan (ORCID: https://orcid.org/0000-0001-6932-6920)
- Muhan Lü (ORCID: https://orcid.org/0000-0002-0527-3695)
- Tao Yang (ORCID: https://orcid.org/0000-0002-0961-9542)
- Hao Li (ORCID: https://orcid.org/0000-0001-5677-3377)
- Sha Liu (ORCID: https://orcid.org/0000-0002-6710-8126)
- Wei Yan (ORCID: https://orcid.org/0000-0003-0619-5876)
- Wanmeng Xiao
- Qian Jia (ORCID: https://orcid.org/0000-0002-3417-4880)
- Zehui Yu (ORCID: https://orcid.org/0000-0003-0435-1548)
Institutions
- Southwest Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
Publication Details
- Journal
- Hereditas
- Published
- 2025-02-12
- DOI
- https://doi.org/10.1186/s41065-025-00378-8
- Citations
- 1
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00