Troponin i-induced cardiac inflammation and dysfunction in mice: a comparative study with the AT-3 tumor-bearing model
Recombinant cTnI induces myocardial contractile dysfunction and promotes a cytotoxic immune response, supporting its role as an autoantigen in myocarditis. Advanced cardiac MRI revealed subtle functional impairments that EF alone could not detect. These findings highlight the potential for therapies targeting cTnI-induced autoimmunity, particularly in patients with ICI-associated myocarditis.
Authors
- Umesh C. Sharma (ORCID: https://orcid.org/0000-0003-0476-2523)
- Swati D. Sonkawade
- Badri Karthikeyan (ORCID: https://orcid.org/0000-0003-2730-2087)
- Sarmila Nepali (ORCID: https://orcid.org/0000-0002-2384-421X)
- Victoire-Grace Karambizi
- P. V. Kulkarni (ORCID: https://orcid.org/0000-0003-3886-7067)
- Shirley Xu
- Saraswati Pokharel (ORCID: https://orcid.org/0000-0002-4104-462X)
Institutions
- Roswell Park Comprehensive Cancer Center (US)
- University at Buffalo, State University of New York (US)
Publication Details
- Journal
- Cardio-Oncology
- Published
- 2025-02-12
- DOI
- https://doi.org/10.1186/s40959-025-00315-8
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Heart, Lung, and Blood Institute
- National Cancer Institute