In-vitro Evaluation of Solution Pressurised Metered Dose Inhaler Sprays with Low-GWP Propellants
Plume stability is a driver of differences between formulations in the near-orifice region. Shot-to-shot repeatability differences are more pronounced ex-mouthpiece, where mixing with ambient air is dominant. Modifications to low-GWP pMDI product actuator orifice and mouthpiece geometries may provide a route to improved in-vitro product bioequivalence relative to current pMDIs. Differences between formulations are modest and may be managed through a combination of formulation, orifice and mouthpiece geometry changes. These generic formulations provide a database of benchmark data against which the performance of low-GWP products may be compared.
Authors
- Paul M. Young (ORCID: https://orcid.org/0000-0002-4357-7999)
- Daniel J. Duke (ORCID: https://orcid.org/0000-0001-8692-6493)
- Stephen W. Stein (ORCID: https://orcid.org/0009-0007-9381-6170)
- Hui Xin Ong (ORCID: https://orcid.org/0000-0002-2882-1551)
- Benjamin Myatt (ORCID: https://orcid.org/0000-0001-8599-9770)
- Nirmal Marasini (ORCID: https://orcid.org/0000-0002-1958-2050)
- Lingzhe Rao (ORCID: https://orcid.org/0000-0003-2141-0298)
- Phil Cocks
Institutions
- Woolcock Institute of Medical Research (AU)
- Kindeva Drug Delivery (United States) (US)
- Monash University (AU)
- Macquarie University (AU)
Publication Details
- Journal
- Pharmaceutical Research
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1007/s11095-025-03830-6
- Citations
- 7
- Primary Topic
- Inhalation and Respiratory Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 10.63
Funders
- National Computational Infrastructure
- Australian Government
- Australian Research Council
- National Cancer Institute
- Argonne National Laboratory