Mebendazole induces ZBP-1 mediated PANoptosis of acute myeloid leukemia cells by targeting TUBA1A and exerts antileukemia effect
These results highlight the remarkable clinical translational potential of MBD, providing new potential medicine for AML patients. In addition, TUBA1A can be used potential novel therapeutic target in tumors with abnormal TUBA1A expression.
Authors
- Qiaoxia Zhang (ORCID: https://orcid.org/0000-0003-2590-9440)
- Ronglin Chen
- Zesong Li (ORCID: https://orcid.org/0000-0003-0975-4434)
- Wei Yang (ORCID: https://orcid.org/0000-0002-4784-9832)
- Shuai Liu (ORCID: https://orcid.org/0000-0002-0699-2296)
- Lin Gao (ORCID: https://orcid.org/0000-0002-5971-8012)
- Ying Xu (ORCID: https://orcid.org/0000-0003-4211-4156)
- Xiongfei Sun
- Obaid Habib
- Xina Xie
- Shi Li
Institutions
- Southern University of Science and Technology (CN)
- Longgang Central Hospital (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Shenzhen Second People's Hospital (CN)
- Fourth People's Hospital of Shenzhen (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-02-12
- DOI
- https://doi.org/10.1016/j.jare.2025.02.013
- Citations
- 4
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 7.08
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Science, Technology and Innovation Commission of Shenzhen Municipality