Static proton arc therapy: Comprehensive plan quality evaluation and first clinical treatments in patients with complex head and neck targets
Static PAT plans demonstrate the capability to increase plan quality with respect to state-of-the-art MFO planning, since dose reduction outside of the target is significant with no reduction of the quality of the target dose distribution. NTCP evaluations, as well as linear energy transfer (LET) distributions, do not indicate risks for unexpected toxicity. Delivery time tests with different beam direction configurations have shown that PAT plans can already be delivered within similar time slots as highly conformal MFO plans. The successful end-to-end commissioning led to the world's first patient treatments using PAT, with eight patients treated to date.
Authors
- Mattia Bertolini
- Stefano Lorentini (ORCID: https://orcid.org/0000-0003-3202-2581)
- Erik Engwall (ORCID: https://orcid.org/0000-0001-8161-4829)
- Irene Giacomelli (ORCID: https://orcid.org/0000-0002-4589-287X)
- Frank Lohr
- Otte Marthin
- Viktor Wase
- Marco Cianchetti
- Roberto Righetto (ORCID: https://orcid.org/0000-0002-9093-5939)
- Johan Sundström (ORCID: https://orcid.org/0000-0003-2247-8454)
- Benedetta Siniscalchi (ORCID: https://orcid.org/0000-0002-2668-7491)
- Victor Mikhalev (ORCID: https://orcid.org/0000-0002-5742-7553)
- Annalisa Trianni (ORCID: https://orcid.org/0009-0002-4969-0359)
- Francesco Fracchiolla
Institutions
- University of Trento (IT)
- Ospedale Santa Chiara (IT)
- Provincia Autonoma di Trento (IT)
- RaySearch Laboratories (Sweden) (SE)
Publication Details
- Journal
- Medical Physics
- Published
- 2025-02-12
- DOI
- https://doi.org/10.1002/mp.17669
- Citations
- 7
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 10.63