Liver fibrosis progression analyzed with AI predicts renal decline
The study shows that liver fibrosis progression assessed by qFibrosis may be associated with renal function decline, which provides a new perspective for understanding complex pathological processes. A combination of artificial intelligence and digital pathology may earlier and more precisely quantify the progression of regional liver fibrosis, thus better identifying changes in renal function. This opens the possibility of early interventions, which are essential to improve patients' outcomes.
Authors
- Sui‐Dan Chen (ORCID: https://orcid.org/0000-0002-5226-8573)
- Hai‐Yang Yuan
- Lai Wei (ORCID: https://orcid.org/0000-0001-7519-627X)
- Yayun Ren (ORCID: https://orcid.org/0000-0002-8613-5728)
- Ming‐Hua Zheng (ORCID: https://orcid.org/0000-0003-4984-2631)
- Dan‐Qin Sun (ORCID: https://orcid.org/0000-0002-8704-3606)
- Hong You (ORCID: https://orcid.org/0000-0001-9409-1158)
- Arun Jayant Sanyal (ORCID: https://orcid.org/0000-0001-8682-5748)
- Giovanni Targher (ORCID: https://orcid.org/0000-0002-4325-3900)
- Dean Tai (ORCID: https://orcid.org/0000-0002-6166-5618)
- Christopher D. Byrne (ORCID: https://orcid.org/0000-0001-6322-7753)
- Yangyang Li (ORCID: https://orcid.org/0000-0002-5791-9443)
- Xiaodong Wang (ORCID: https://orcid.org/0000-0002-4246-9267)
- Xinlei Wang (ORCID: https://orcid.org/0000-0001-8658-223X)
- Vincent Wai‐Sun Wong (ORCID: https://orcid.org/0000-0003-2215-9410)
- Jiaqi Shen (ORCID: https://orcid.org/0000-0002-7435-4106)
- Pei‐Wu Zhu
- Xiaofei Tong
Institutions
- Jiangnan University (CN)
- University of Verona (IT)
- Chinese University of Hong Kong (HK)
- Capital Medical University (CN)
- Virginia Commonwealth University (US)
- Nantong University (CN)
- Wenzhou Medical University (CN)
- Southampton General Hospital (GB)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- University Hospital Southampton NHS Foundation Trust (GB)
- Ospedale Sacro Cuore Don Calabria (IT)
- Wuxi No.2 People's Hospital (CN)
- Beijing Friendship Hospital (CN)
- Beijing Tsinghua Chang Gung Hospital (CN)
- Histoindex (Singapore) (SG)
- University of Southampton (GB)
- Tsinghua University (CN)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-02-12
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101358
- Citations
- 7
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 9.48
Funders
- National Institute for Health and Care Research
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- National Science and Technology Major Project
- National Institute for Health Research Southampton Biomedical Research Centre