Multicenter evaluation of abbreviated MRI and ultrasound for detecting early-stage hepatocellular carcinoma

Abbreviated MRI (AMRI) is increasingly recognized as an alternative to ultrasound for hepatocellular carcinoma (HCC) surveillance. However, existing data are limited by single-center samples, spectrum bias, and lack of comparative data for AMRI <i>vs.</i> ultrasound. We found that AMRI had significantly higher per-patient sensitivity and specificity compared with ultrasound for the detection of early-stage HCC, although its relative benefit might be smaller in patients with Child-Pugh A cirrhosis, and both modalities underperformed in patients with Child-Pugh C cirrhosis. If sufficiently validated, AMRI could be adopted into practice guidelines for HCC surveillance and serve as a preferred alternative in select subgroups of patients.

Authors

Institutions

Publication Details

Journal
JHEP Reports
Published
2025-02-13
DOI
https://doi.org/10.1016/j.jhepr.2025.101357
Citations
2
Primary Topic
Liver Disease Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
2.71

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Multicenter evaluation of abbreviated MRI and ultrasound for detecting early-stage hepatocellular carcinoma

Amit G. Singal, Neehar D. Parikh, Edward Yang, Darine Daher et al.
2 citations
JHEP Reports
Liver Disease Diagnosis and Treatment
2.71
article

Multicenter evaluation of abbreviated MRI and ultrasound for detecting early-stage hepatocellular carcinoma

Amit G. Singal, Neehar D. Parikh, Edward Yang, Darine Daher, David T. Fetzer, Takeshi Yokoo, Matthew S. Davenport, Mishal Mendiratta‐Lala, Karim Seif El Dahan, Nicole E. Rich
article en
2 citations

Abstract

Abbreviated MRI (AMRI) is increasingly recognized as an alternative to ultrasound for hepatocellular carcinoma (HCC) surveillance. However, existing data are limited by single-center samples, spectrum bias, and lack of comparative data for AMRI <i>vs.</i> ultrasound. We found that AMRI had significantly higher per-patient sensitivity and specificity compared with ultrasound for the detection of early-stage HCC, although its relative benefit might be smaller in patients with Child-Pugh A cirrhosis, and both modalities underperformed in patients with Child-Pugh C cirrhosis. If sufficiently validated, AMRI could be adopted into practice guidelines for HCC surveillance and serve as a preferred alternative in select subgroups of patients.

JHEP ReportsVol. 7(5)
University of Michigan (US), Southwestern Medical Center (US), Kaiser Permanente Riverside Medical Center (US), Southwestern Medical Center (US), The University of Texas Southwestern Medical Center (US)
Cancer Prevention and Research Institute of Texas, National Institutes of Health, National Cancer Institute
Good health and well-being
Openalex Percentile: Top 12%
Liver Disease Diagnosis and Treatment
2.71
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Multicenter evaluation of abbreviated MRI and ultrasound for detecting early-stage hepatocellular carcinoma — Amit G. Singal, Neehar D. Parikh, et al. · JHEP Reports (2025) | TGRS Research Map | TGRS