Identification of therapeutic targets and immune landscape in glioblastoma through crosstalk with glioma-associated mesenchymal stem cells
This study revealed the co-expression patterns and metabolic pathways between GA-MSCs and GBM, providing new insights into the molecular mechanisms of GBM progression. Targeting FLNC with staurosporine presents a promising therapeutic strategy for GBM. Aditionally, targeting the shared pathways of both may offer a valuable approach for treating malignant brain tumors.
Authors
- Wei Xiang (ORCID: https://orcid.org/0000-0002-8331-1407)
- Haoyang Zheng (ORCID: https://orcid.org/0000-0001-6835-8242)
- Yong Ping Gan (ORCID: https://orcid.org/0000-0002-4579-994X)
- Duo Zhang (ORCID: https://orcid.org/0000-0003-0361-4174)
- Haofei Wang (ORCID: https://orcid.org/0000-0001-5337-2420)
- Yuyi Wu
- Peng Fu
Institutions
- Wuhan Union Hospital (CN)
- Tongji Hospital (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-02-12
- DOI
- https://doi.org/10.1016/j.intimp.2025.114228
- Citations
- 2
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.25
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province