Role of declined electrogenic Na+/HCO3– cotransporter NBCe1 in mucus barrier impairment and colonic inflammation
NBCe1 has been identified as a valuable signature gene may have a protective effect against the onset of colitis. Function of NBCe1 is diminished in colitis, which is associated with impaired mucus barrier and declined HCO<sub>3</sub><sup>-</sup> secretion both contributing to the development of IBD.
Authors
- Xiaohua Hou (ORCID: https://orcid.org/0000-0002-3694-2126)
- Jun Song (ORCID: https://orcid.org/0000-0001-9970-8313)
- Jing He
- Lei Zhang (ORCID: https://orcid.org/0000-0001-6302-8383)
- Jiacheng Wu (ORCID: https://orcid.org/0000-0002-9022-8169)
- Tao Bai (ORCID: https://orcid.org/0000-0002-4268-4194)
- Pengcheng Yang (ORCID: https://orcid.org/0000-0002-7359-9195)
- Jun Tan (ORCID: https://orcid.org/0009-0004-8249-8363)
Institutions
- Wuhan Union Hospital (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-02-12
- DOI
- https://doi.org/10.1016/j.intimp.2025.114282
- Primary Topic
- Ion Transport and Channel Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China