Copper-enriched automotive brake wear particles perturb human alveolar cellular homeostasis
We demonstrate here that brake-wear PM may perturb cellular homeostasis more than diesel exhaust PM. Our findings demonstrate the potential differences in effects, not only for non-exhaust vs exhaust PM, but also amongst different sources of non-exhaust PM. This has implications for our understanding of the potential health effects of road vehicle-associated PM. More broadly, our findings illustrate the importance of PM composition on potential health effects, highlighting the need for targeted legislation to protect public health.
Authors
- Julian Downward (ORCID: https://orcid.org/0000-0002-2331-4729)
- James Parkin (ORCID: https://orcid.org/0009-0008-7590-6233)
- Miriam E. Gerlofs-Nijland (ORCID: https://orcid.org/0000-0003-1318-004X)
- Donna E. Davies (ORCID: https://orcid.org/0000-0002-5117-2991)
- Joseph A. Bell (ORCID: https://orcid.org/0000-0002-3922-4795)
- Natasha H. C. Easton (ORCID: https://orcid.org/0000-0002-9168-3294)
- Franco Conforti (ORCID: https://orcid.org/0000-0001-5305-3155)
- Flemming R. Cassee (ORCID: https://orcid.org/0000-0001-9958-8630)
- Lareb S. N. Dean (ORCID: https://orcid.org/0000-0002-8703-9236)
- Matthew Loxham (ORCID: https://orcid.org/0000-0001-6459-538X)
- Richard Cook (ORCID: https://orcid.org/0000-0002-2468-5820)
- Robert A. Ridley
- Siyuan Wang (ORCID: https://orcid.org/0000-0001-6792-7482)
- Yihua Wang (ORCID: https://orcid.org/0000-0001-5561-0648)
- Juanjuan Li (ORCID: https://orcid.org/0000-0003-2164-094X)
- Mark G. Jones (ORCID: https://orcid.org/0000-0001-6308-6014)
- Matthew J. Cooper
- Hasumati Raj
- Liudi Yao (ORCID: https://orcid.org/0009-0002-3713-8735)
- Liam J. Edgeway
Institutions
- Utrecht University (NL)
- The Francis Crick Institute (GB)
- University Hospital Southampton NHS Foundation Trust (GB)
- National Institute for Public Health and the Environment (NL)
- NIHR Southampton Biomedical Research Centre (GB)
- University of Southampton (GB)
Publication Details
- Journal
- Particle and Fibre Toxicology
- Published
- 2025-02-13
- DOI
- https://doi.org/10.1186/s12989-024-00617-2
- Citations
- 12
- Primary Topic
- Air Quality and Health Impacts
- Type
- article
- Field-Weighted Citation Impact
- 14.40
Funders
- Leverhulme Trust
- Academy of Medical Sciences
- University of Southampton
- University of Oxford
- AAIR Charity
- Wessex Medical Research
- National Institute for Health Research Southampton Biomedical Research Centre
- Directorate for Biological Sciences
- Medical Research Council
- Biotechnology and Biological Sciences Research Council