Rapid Assembly of Oxatricyclo[3.2.1.02,7]octanes

Abstract Cyclopropane-incorporated oxapolycyclic bridged molecules are often architecturally intriguing, synthetically useful, and biologically important. However, strategies for constructing such complex structures are relatively limited. This paper reviews representative methods that provide rapid access to a specific class of oxatricyclooctane frameworks containing cyclopropane, oxatricyclo[3.2.1.02,7]octane. A recent example of enantioselective construction of such a complex oxatricyclooctane structure is presented. 1 Introduction 2 Racemic Synthesis of Oxatricyclo[3.2.1.02,7]octanes 3 Enantioselective Synthesis of Oxatricyclo[3.2.1.02,7]octanes 4 Conclusion