Association of killer cell immunoglobulin-like receptor genes with primary Sjögren’s syndrome among Chinese population
Our results may imply that via influencing the activity, development, capacitation, and functionality of NK cells, NKT cells, and part T cells, the decrease of activated KIR genes and the increase of the frequency of the inhibitory KIR and its specific ligand gene combination（KIR2DL1/HLA-C2) may contribute to the pathogenesis of pSS.
Authors
- Shumin Zhang
- Wenjing Yue
- Jing Xu (ORCID: https://orcid.org/0000-0002-9506-5514)
- Anhao Zheng (ORCID: https://orcid.org/0000-0001-8679-9682)
- Wenbin Chen (ORCID: https://orcid.org/0000-0002-8389-8535)
- Hongsheng Sun
- Ye Yuan
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Shandong Provincial Hospital (CN)
- Heze Municipal Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Human Immunology
- Published
- 2025-02-12
- DOI
- https://doi.org/10.1016/j.humimm.2025.111262
- Primary Topic
- Salivary Gland Disorders and Functions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Shandong First Medical University