High Prevalence of Ceftriaxone-Resistant <i>Neisseria gonorrhoeae</i> in Hanoi, Vietnam, 2023–2024
Ceftriaxone resistance in Neisseria gonorrhoeae is an escalating global health concern, threatening the efficacy of empiric treatment. In the Asia-Pacific region, a rapid surge in ceftriaxone resistance has been observed, primarily associated with the penA-60.001 allele. This study, conducted in Hanoi, Vietnam between 2023 and 2024, analyzed 352 N. gonorrhoeae isolates and found a 27% prevalence of ceftriaxone resistance. Whole-genome sequencing identified that resistance was predominantly driven by the mosaic penA-237.001 allele, with a smaller contribution from penA-60.001. The high prevalence of resistance and the emergence of new alleles underscore the urgent threat to ceftriaxone as an empiric treatment option.
Authors
- Koen Vandelannoote (ORCID: https://orcid.org/0000-0001-8367-4083)
- Vu Ngoc Hieu (ORCID: https://orcid.org/0000-0001-7877-3001)
- H. Rogier van Doorn (ORCID: https://orcid.org/0000-0002-9807-1821)
- Thomas Kesteman (ORCID: https://orcid.org/0000-0002-7951-8261)
- Tam Nguyen (ORCID: https://orcid.org/0000-0002-0282-7760)
- Trần Minh Châu
- Paul C. Adamson (ORCID: https://orcid.org/0000-0002-2776-6458)
- Hong Nhung Pham (ORCID: https://orcid.org/0000-0002-4543-8386)
- Jolein Laumen (ORCID: https://orcid.org/0000-0003-0168-5622)
- Trang Tu Nguyen
- Nguyễn Thị Ngọc Diệp (ORCID: https://orcid.org/0009-0000-8571-0113)
Institutions
- University of California, Los Angeles (US)
- Hanoi Medical University (VN)
- University of Oxford (GB)
- Institut Pasteur du Cambodge (KH)
- Oxford University Clinical Research Unit (VN)
- Bạch Mai Hospital (VN)
- Hanoi Medical University Hospital (VN)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-02-10
- DOI
- https://doi.org/10.1093/infdis/jiaf071
- Citations
- 19
- Primary Topic
- Reproductive tract infections research
- Type
- article
- Field-Weighted Citation Impact
- 22.48
Funders
- National Institutes of Health
- Fogarty International Center