The effect of the liposomal drug “Lipointersil” on the antioxidant status of the body of bulls under heavy metal loading

The accumulation of cadmium and lead in the components of the natural environment increases the risk of their entry into the animal body and threatens their health. This study aimed to study the effect of the liposomal preparation “Lipointersyl,” based on interferon and milk thistle, on the antioxidant status of the body of bulls under conditions of toxic loading with Cadmium and Lead. The studies were conducted on young six-month-old cattle of the Ukrainian black-and-white dairy breed at the agricultural enterprise “Ukraine” of the Dubrovytskyi district of the Rivne region, where high levels of these metals were found in the feed. When using the liposomal preparation “Lipointersil” in bulls, a decrease in lipid peroxidation processes was established. The components of the liposomal preparation reduced the level of intermediate and final products of lipid peroxidation, particularly diene conjugates, by 22.3 % and TBA-active products by 20 %. Intramuscular administration of the preparation contributed to the enhancement of antioxidant protection, which was confirmed by an increase in the level of reduced glutathione in the blood by 9.8% by the 30th day of the experiment. The activity of glutathione peroxidase and glutathione reductase increased by 24.1 % and 27.7 %, respectively, was also noted. The study results on young cattle show that the liposomal preparation “Lipointersil,” under conditions of toxic load with Cadmium and Lead, activates the glutathione system of antioxidant protection, improving the system's enzymatic and non-enzymatic links. The activity of catalase and superoxide dismutase in the blood of bulls of the experimental group remained within physiological values. Therefore, the liposomal preparation “Lipointersil” exhibits antioxidant properties and is recommended for use in young cattle in conditions of heavy metal contamination to prevent oxidative stress.