Ginsenoside 1 mitigates postoperative cognitive dysfunction by enhancing microglial Aβ clearance through the endo-lysosomal pathway
In conclusion, our study demonstrates that Rg1 can effectively ameliorate cognitive and synaptic deficit by enhancing microglial Aβ clearance through the endo-lysosomal pathway in aged POCD mice, which provides a potential strategy for the prevention of POCD.
Authors
- Gang Wang (ORCID: https://orcid.org/0000-0003-4882-5389)
- Yongchang Zhao (ORCID: https://orcid.org/0000-0003-1494-4259)
- Weiqian Tian (ORCID: https://orcid.org/0000-0001-7474-4203)
- Jing Xu (ORCID: https://orcid.org/0000-0003-3453-250X)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Xuzhou Medical College (CN)
- Soochow University (CN)
- Second People’s Hospital of Huai’an (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-02-12
- DOI
- https://doi.org/10.1016/j.intimp.2025.114281
- Citations
- 5
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 4.21
Funders
- Nanjing Institute of Astronomical Optics and Technology, Chinese Academy of Sciences