Association between tumour necrosis factor-a polymorphism and cervical cancer in Lagos State, Nigeria

We observed that HIV-negative and HIV-positive women who carry the C allele of -1031T>C and the A allele of -308G>A <i>TNF-a</i> promoter gene loci, respectively, are more susceptible to CC. We were also able to show protective linkages for the minor allele of the three SNPs of interest suggesting the potential of TNF-a as a surrogate marker for CC screening in addition to human papillomavirus primary testing. Further studies are required to determine the association between host factors and TNF-a polymorphism to harness the diagnostic and therapeutic advantage these associations will provide in the management of CC.