A two-photon lensless endoscope with a double-clad tapered multi-core fiber
We present a novel, to the best of our knowledge, multi-core fiber-based lensless micro-endoscope incorporating several key innovations: a Fermat's golden spiral core layout, a low-index polymer cladding, and a longitudinally varying fiber diameter. This fiber design enables efficient focusing of ultrashort pulses and collection of the fluorescence signal with both diffraction-limited resolution and field of view. These advancements address several long-standing challenges in the development of ultra miniaturized non-linear endoscopes. We characterize the device's performance by evaluating the Strehl ratio, field of view, and memory effect. Finally, we demonstrate its application to biological cellular samples by performing two-photon excited fluorescence imaging in an endoscopic configuration.
Authors
- Géraud Bouwmans (ORCID: https://orcid.org/0000-0001-9107-7115)
- Esben Ravn Andresen (ORCID: https://orcid.org/0000-0002-7522-6165)
- Rosa Cossart (ORCID: https://orcid.org/0000-0003-2111-6638)
- Andy Cassez (ORCID: https://orcid.org/0000-0003-1043-9300)
- Hervé Rigneault (ORCID: https://orcid.org/0000-0001-6007-0631)
- Siddharth Sivankutty (ORCID: https://orcid.org/0000-0001-5079-4409)
- Aymeric Pastre (ORCID: https://orcid.org/0000-0001-7233-231X)
- Luca Genchi (ORCID: https://orcid.org/0000-0002-0808-112X)
- Matthias Höfer (ORCID: https://orcid.org/0000-0001-9256-7765)
- Adrien Carron
- Damien Labat
- Fatima El Moussawi
- Olivier Vanvincq (ORCID: https://orcid.org/0000-0001-6325-6909)
- Remy Bernand
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Aix-Marseille Université (FR)
- Université de Lille (FR)
- Institut de Neurobiologie de la Méditerranée (FR)
- Institut Fresnel (FR)
- Laboratoire de Physique des Lasers, Atomes et Molécules (FR)
- Institut de Recherche sur les Composants logiciels et matériels pour l'Information et la Communication Avancée
Publication Details
- Journal
- Optics Letters
- Published
- 2025-02-12
- DOI
- https://doi.org/10.1364/ol.550709
- Citations
- 1
- Primary Topic
- Optical Coherence Tomography Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.67