Remote cognitive tests predict neurodegenerative biomarkers in the Insight 46 cohort
70% of the Online 46 cohort performed a set of remote online cognitive tasks. Response time and accuracy on a memory task predicted amyloid status and load (SUVR). Accuracy on memory and spatial span tasks correlated with longitudinal atrophy rate. The Cognitron tasks correlated with standard supervised cognitive tests. Online cognitive testing can help identify early AD-related memory deficits.
Authors
- Josephine Barnes (ORCID: https://orcid.org/0000-0003-3178-025X)
- Heidi Murray‐Smith (ORCID: https://orcid.org/0000-0002-1313-7263)
- Kirsty Lu (ORCID: https://orcid.org/0000-0002-8416-2183)
- William R. Trender (ORCID: https://orcid.org/0000-0003-3947-5532)
- Marguerite Leoni (ORCID: https://orcid.org/0000-0003-1078-0533)
- Paresh Malhotra (ORCID: https://orcid.org/0000-0002-1897-0780)
- Sebastian J. Crutch (ORCID: https://orcid.org/0000-0002-4160-0139)
- Adam Hampshire (ORCID: https://orcid.org/0000-0002-5176-5420)
- David M. Cash (ORCID: https://orcid.org/0000-0001-7833-616X)
- Valentina Giunchiglia (ORCID: https://orcid.org/0000-0002-2165-7840)
- Carole H. Sudre (ORCID: https://orcid.org/0000-0001-5753-428X)
- Jonathan M. Schott (ORCID: https://orcid.org/0000-0003-2059-024X)
- Andrew Wong (ORCID: https://orcid.org/0000-0003-2079-4779)
- Martina Del Giovane (ORCID: https://orcid.org/0000-0002-3476-8494)
- Marcus Richards (ORCID: https://orcid.org/0000-0001-9191-2192)
- Rebecca E Street
- Thomas D. Parker
- Peter John Hellyer (ORCID: https://orcid.org/0000-0002-5139-3401)
- Maria Popham (ORCID: https://orcid.org/0000-0003-4286-7166)
- Ziyuan Cai
- Jennifer Nicholas
Institutions
- Harvard University (US)
- King's College London (GB)
- Hammersmith Hospital (GB)
- University of Surrey (GB)
- London School of Hygiene & Tropical Medicine (GB)
- UK Dementia Research Institute (GB)
- MRC Unit for Lifelong Health and Ageing (GB)
- The London College (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- Imperial College London (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/alz.14572
- Citations
- 5
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 7.36
Funders
- Alzheimer's Association
- LifeArc
- Alzheimer's Society
- National Institute for Health and Care Research
- British Heart Foundation
- Brain Research Trust
- Wolfson Foundation
- University College London Hospitals NHS Foundation Trust
- Dementias Platform UK
- California State University, Bakersfield
- Medical Research Council
- UCLH Biomedical Research Centre
- NIHR Imperial Biomedical Research Centre