MITOCHONDRIAL DYSFUNCTION IN BONE DENSITY METABOLISM IN PATIENTS WITH OPIOID USE DISORDER UNDER METHADONE MAINTENANCE TREATMENT

Abstract Background Recent studies have also shown that mitochondrial function and oxidative stress might play important roles in bone metabolism. Whether patients with opioid use disorder (OUD) experienced a decrease in bone density and an increased risk of osteoporosis and fractures through this mechanism is still unknown. Therefore, we examined the mitochondrial function between health control subjects the OUD patients under methadone maintenance treatment. Methods We conducted a cross-sectional cohort study. Patients with OUD receiving methadone maintenance treatment in Changhua Christian Hospital in Taiwan were recruited. We compared the difference between patients with OUD and without OUD in Mitochondrial DNA (mtDNA) copy number, oxidative modification of mtDNA index(mtDNA(DeltaCT)), and 8-hydroxy-2'-deoxyguanosine. Results Finally, 29 patients from MMT were allocated in opioid group. 37 health control subjects were allocated in control group. Patients in opioid group had significantly lower mtDNA than those in control group. Besides, patients in opioid group also had significantly lower DeltaCT and 8-hydroxy-2'-deoxyguanosine than those in control group. Conclusions Mitochondrial dysfunction was found in patients with OUD in our study. The precise role of mitochondrial dysfunction in bone density metabolism in this population should be further investigated. References Wen-Yu Hsu, et al. (2019) Association between opioid use disorder and fractures: a population-based study. Addiction. 114(11):2008-2015. Wen-Yu Hsu, et al. (2018) Medications Used for Cognitive Enhancement in Patients With Schizophrenia, Bipolar Disorder, Alzheimer's Disease, and Parkinson's Disease. Frontiers in Psychiatry. 9:91.