A heroin overdose laboratory model: How do escalating doses of diamorphine alter respiratory function in a diamorphine‐treated population?
A dose-escalation clinical trial of people prescribed injectable diamorphine for heroin addiction found that the degree of respiratory depression caused by diamorphine does not appear to be dose dependent; however, the changes seen at diamorphine doses to which participants were accustomed suggest that participants had only partial tolerance to the respiratory depressant effect of diamorphine.
Authors
- Caroline J. Jolley (ORCID: https://orcid.org/0000-0003-3538-2451)
- Mike Kelleher
- Nicola J. Kalk (ORCID: https://orcid.org/0000-0002-3820-9243)
- Rob van der Waal (ORCID: https://orcid.org/0000-0001-5751-641X)
- John Strang (ORCID: https://orcid.org/0000-0002-5413-2725)
- Basak Tas (ORCID: https://orcid.org/0000-0002-3137-7631)
- John Moxham (ORCID: https://orcid.org/0000-0003-0051-651X)
- Edward Chesney (ORCID: https://orcid.org/0000-0003-2851-5252)
- Will Lawn (ORCID: https://orcid.org/0000-0002-0143-2724)
- James Bell (ORCID: https://orcid.org/0000-0002-5117-0216)
- Alastair Boyd
Institutions
- King's College London (GB)
- South London and Maudsley NHS Foundation Trust (GB)
- King's College Hospital NHS Foundation Trust (GB)
- Kings Health Partners (GB)
Publication Details
- Journal
- Addiction
- Published
- 2025-02-10
- DOI
- https://doi.org/10.1111/add.70005
- Citations
- 2
- Primary Topic
- Neuroscience of respiration and sleep
- Type
- article
- Field-Weighted Citation Impact
- 1.83
Funders
- Maudsley Charity
- National Institute for Health and Care Research
- King's College London