Transcriptomic Signatures Predict Rubella Virus‐Induced Cytokine and Chemokine Responses in Female MMR Recipients
The study examined the relationship between rubella virus (RV)-induced gene expression and proinflammatory cytokine/chemokine secretion in females previously vaccinated with MMR. Gene clusters enriched for functional pathways of innate immune system activation and antiviral responses were found to predict RV-specific MCP-1, MCP-4, IP-10, and IL-2 secretion.
Authors
- Huy Quang Quach (ORCID: https://orcid.org/0000-0003-2191-5771)
- Inna G. Ovsyannikova (ORCID: https://orcid.org/0000-0003-1506-9214)
- Richard B. Kennedy
- Diane E. Grill (ORCID: https://orcid.org/0000-0002-8677-1724)
- Krista M. Goergen
- Iana H. Haralambieva (ORCID: https://orcid.org/0000-0002-2856-0590)
- Tamar Ratishvili (ORCID: https://orcid.org/0000-0002-1446-1188)
- Ilya M. Swanson
- Gregory A. Poland
Institutions
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- European Journal of Immunology
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/eji.202451303
- Primary Topic
- Virology and Viral Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of Allergy and Infectious Diseases