Enhanced Efficacy of Radiation Therapy against Glioblastoma by Attenuated Salmonella Carrying Co-Expression Plasmids with siRNA-PD-L1 and Endostatin
These findings highlight the ability of attenuated Salmonella carrying siR-NA-PD-L1 and co-expressing endostatin plasmids to effectively modulate PD-L1 and VEGF expression, thus strengthening the anti-tumor immune response in GBM-bearing mice subjected to radiation therapy. This combination therapy approach holds promise as a potential avenue for improving the efficacy of radiation therapy in the treatment of glio-blastoma.
Authors
- Huijie Jia (ORCID: https://orcid.org/0000-0002-4267-0198)
- Chengbiao Lu (ORCID: https://orcid.org/0000-0003-0719-7937)
- Jiaming Guo (ORCID: https://orcid.org/0000-0002-8035-9237)
- Weiwei Ren
- Peiyuan Dang
- Hanyu Jiang (ORCID: https://orcid.org/0000-0002-7726-1618)
- Tiesuo Zhao
- Jin Yang (ORCID: https://orcid.org/0000-0001-6129-9729)
- Yu Wang (ORCID: https://orcid.org/0000-0001-6308-8626)
- Xin Chen (ORCID: https://orcid.org/0000-0003-4997-1257)
- Mengyu Lei
- Yinghua Ji
- Jiahang Li
- Jiaxin Geng
Institutions
- First Affiliated Hospital of Xinxiang Medical University (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Henan Medical University (CN)
Publication Details
- Journal
- Current Cancer Drug Targets
- Published
- 2025-02-07
- DOI
- https://doi.org/10.2174/0115680096344636250101074632
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00