Construction of the Single‐Cell Landscape of Hashimoto's Thyroiditis Tissue and Peripheral Blood by Single‐Cell RNA Sequencing
The present study further validated the role of immune cells in the pathogenesis of HT at the cellular level. In addition, a new cell subset B_MEF2B_BCL6 was found. It could be speculated that MEF2B mainly transactivates the expression level of the transcriptional repressor BCL6, leading to the development of HT. A new cell subset TFC_PAX8_NKX2-1 was also identified, in which the specific transcription factors PAX8 and NKX2-1 were highly expressed in HT tissues.
Authors
- Jin Zhou (ORCID: https://orcid.org/0000-0002-5534-1123)
- Yuxiao Tang (ORCID: https://orcid.org/0000-0001-7576-8928)
- Yakui Mou (ORCID: https://orcid.org/0000-0003-1367-0145)
- Xiaojie Wang (ORCID: https://orcid.org/0000-0003-4817-5830)
- Qinglin Zhang (ORCID: https://orcid.org/0000-0002-3640-2883)
- Kaiyu Song (ORCID: https://orcid.org/0009-0001-2889-569X)
- Yuantao Wang (ORCID: https://orcid.org/0000-0001-9720-1156)
- Xicheng Song (ORCID: https://orcid.org/0000-0002-9789-1318)
- Wenjie Yao
Institutions
- Qingdao University (CN)
- Weifang Medical University (CN)
- Binzhou Medical University (CN)
- Shandong University of Aeronautics (CN)
- Yuhuangding Hospital (CN)
Publication Details
- Journal
- Immunity Inflammation and Disease
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/iid3.70153
- Citations
- 3
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Natural Science Foundation of China
- China Scholarship Council
- Key Technology Research and Development Program of Shandong