Catalyst‐Free Synthesis of Substituted Thiazole‐2‐Imine Derivatives in a Mortar, and Their Photophysical Study

Abstract In this study, for the first time we devised a one‐pot telescopic method for synthesizing thiazol‐2( 3H )‐imine using mortar‐pestle grinding under solvent‐free conditions. The reaction involves isothiocyanate, primary amine, and α‐bromoketones as precursors. The protocol demonstrated a broad substrate scope of 19 derivatives confirmed by various spectroscopic techniques. The reported approach is simple to operate, has mild reaction conditions, and affords the desired products in good to outstanding yields up to 98% in 10 to 20 min. UV‐visible and fluorescence spectroscopic techniques were used to investigate the photophysical characteristics of 9 selected thiazol‐2( 3H )‐imine derivatives. The absorption and emission spectra show a maximum peak wavelength (λmax) at 295 ̶ 305 nm and 369 ̶ 370 nm, respectively.