Ex Vivo and In Vitro Proteomic Approach to Elucidate the Relevance of <scp>IL</scp>‐4 and <scp>IL</scp>‐10 in Intervertebral Disc Pathophysiology
The NP cell phenotype affects the pleiotropic role of IL-4, which can induce a pro-inflammatory response in the presence of catabolic stimuli and enhance the effects of IL-1β in degenerated IVDs. Environmental factors, including 3D culture and hypoxia, may alter IL-4's role. Finally, IL-10's potential neurotrophic effects under catabolic stimuli warrant further investigation to clarify its role in IVD degeneration.
Authors
- Exarchos Kanelis (ORCID: https://orcid.org/0000-0002-2059-1480)
- Jérôme Noailly (ORCID: https://orcid.org/0000-0003-3446-7621)
- Karin Wuertz‐Kozak (ORCID: https://orcid.org/0000-0002-3281-4629)
- Benjamin Gantenbein (ORCID: https://orcid.org/0000-0002-9005-0655)
- Katherine B. Crump (ORCID: https://orcid.org/0000-0001-5328-667X)
- Leonidas G. Alexopoulos (ORCID: https://orcid.org/0000-0003-0425-166X)
- Paola Bermudez‐Lekerika (ORCID: https://orcid.org/0000-0002-6858-8213)
- Sofia Tseranidou
- Christine L. Le Maitre (ORCID: https://orcid.org/0000-0003-4489-7107)
- Andrea Nüesch (ORCID: https://orcid.org/0000-0002-0962-8705)
Institutions
- University of Bern (CH)
- Rochester Institute of Technology (US)
- Universitat Pompeu Fabra (ES)
- National Technical University of Athens (GR)
- National Centre of Scientific Research "Demokritos" (GR)
- University Hospital of Bern (CH)
- Schön Klinik München Harlaching (DE)
- University of Sheffield (GB)
Publication Details
- Journal
- JOR Spine
- Published
- 2025-02-10
- DOI
- https://doi.org/10.1002/jsp2.70048
- Citations
- 6
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 8.83
Funders
- University of Bern
- H2020 Marie Skłodowska-Curie Actions