Improved Survival in Vascular Pythiosis With Surgery and Azithromycin, Doxycycline, and Itraconazole Therapy: A Phase II Multicenter, Open-Label, Single-Arm Trial
The combination therapy of surgery, azithromycin, doxycycline, and itraconazole improves survival in patients with vascular pythiosis, including those with residual disease. This regimen is well tolerated and should be considered a standard of care, with further research needed for long-term outcomes.
Authors
- Rattagan Kajeekul (ORCID: https://orcid.org/0000-0001-5067-5389)
- Achitpol Thongkam (ORCID: https://orcid.org/0000-0002-7279-1062)
- Ratiporn Bansong
- Karan Srisurapanont (ORCID: https://orcid.org/0000-0001-9296-6344)
- Jaruwan Diewsurin (ORCID: https://orcid.org/0000-0003-2389-0897)
- Tanaporn Meejun (ORCID: https://orcid.org/0000-0002-9544-7096)
- Navaporn Worasilchai (ORCID: https://orcid.org/0000-0001-5055-6830)
- Kanokwan Laohasakprasit
- Watchara Wattanasoontornsakul
- Sureerat Watcharasuwanseree
- Ariya Chindamporn (ORCID: https://orcid.org/0000-0002-9761-1670)
- Kasama Manothummetha (ORCID: https://orcid.org/0000-0002-2446-143X)
- Nuttapon Susaengrat (ORCID: https://orcid.org/0000-0002-1128-8113)
- Nitipong Permpalung (ORCID: https://orcid.org/0000-0002-0749-7342)
- Surachai Leksuwankun (ORCID: https://orcid.org/0000-0002-0854-3056)
- Nattapong Langsiri (ORCID: https://orcid.org/0000-0002-1889-7122)
- Jaedvara Thanakitcharu (ORCID: https://orcid.org/0000-0003-1880-5387)
- Sunee Chayangsu (ORCID: https://orcid.org/0000-0002-5563-9501)
- Rongpong Plongla (ORCID: https://orcid.org/0000-0002-1622-1209)
- Nirada Siriyakorn
- Nipat Chuleerarux (ORCID: https://orcid.org/0000-0001-9474-637X)
- Parichart Sakulkonkij (ORCID: https://orcid.org/0000-0002-1481-1950)
- Supphachoke Khemla
- Pattama Torvorapanit (ORCID: https://orcid.org/0000-0001-9507-6339)
- Bhoowit Lerttiendamrong (ORCID: https://orcid.org/0000-0003-0143-6407)
- Poom Chayapum
- Pinyo Suparatanachatpun
- Thanyarak Wongkamha
- Prasopchai Kongsakpaisal
Institutions
- Nakhon Phanom University (TH)
- Thai Red Cross Society (TH)
- Siriraj Hospital (TH)
- Johns Hopkins University (US)
- University of Miami (US)
- Chulalongkorn University (TH)
- Khon Kaen University (TH)
- Mahidol University (TH)
- Johns Hopkins Medicine (US)
- King Chulalongkorn Memorial Hospital (TH)
- Jackson Memorial Hospital (US)
- An-Nan Hospital (TW)
- Maharat Nakhon Ratchasima Hospital (TH)
- Rajavithi Hospital (TH)
- Prapokklao Hospital (TH)
- Buddhachinaraj Hospital (TH)
- Lampang Hospital (TH)
- Nakhon Pathom Rajabhat University (TH)
- Charoenkrung Pracharak Hospital (TH)
- Surin Hospital (TH)
- Udon Thani Hospital (TH)
- Chiang Mai University (TH)
- Srinakharinwirot University (TH)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1093/cid/ciaf062
- Citations
- 5
- Primary Topic
- Infectious Diseases and Mycology
- Type
- article
- Field-Weighted Citation Impact
- 11.77