Prevalence of Human Leukocyte Antigen (<scp>HLA</scp>)‐B*58:01 and Allopurinol‐Induced Adverse Reactions in Filipino Patients in Hawai'i: Implications for Genotyping
The high prevalence of HLA-B*58:01 allele among Filipino patients in Hawai'i suggests that genotyping may be considered before initiating allopurinol treatment. Given no instances of SCAR were observed in patients who were administered allopurinol after undergoing HLA-B*58:01 genotyping, genotyping may play a crucial role in reducing the risk of allopurinol-induced SCAR in this population. Further studies with larger cohorts are suggested to confirm our findings and assess broader clinical utility of genotyping.
Authors
- Huckie C. Del Mundo
- Alejandro Medina (ORCID: https://orcid.org/0000-0001-5609-2969)
- Rika Terashima (ORCID: https://orcid.org/0000-0002-3650-9269)
- Charlie Y. Sonido
- Rhea A. Bautista
- Seiji Yamada (ORCID: https://orcid.org/0000-0002-5258-4488)
- Ryan Sean S. Briones
- Yuh Miin Sin
- Jacqueline Del Carmen Aquino
- Ellaine M. Quiminiano
Institutions
- University of Hawaiʻi at Mānoa (US)
- A.T. Still University (US)
- Stanford University (US)
Publication Details
- Journal
- International Journal of Rheumatic Diseases
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1111/1756-185x.70127
- Citations
- 2
- Primary Topic
- Drug-Induced Adverse Reactions
- Type
- article
- Field-Weighted Citation Impact
- 2.79