Thermodynamic Properties of Betamethasone Dipropionate

Precision adiabatic vacuum and high-precision differential scanning calorimetry (DSC) are used to study the temperature dependence of the heat capacity of betamethasone dipropionate in the range of 6–520 K for the first time. A phase transition of betamethasone dipropionate (melting) is detected in the above range of temperatures, and its thermodynamic characteristics are calculated. The low temperature heat capacity (20 ≤ T ≤ 50 K) is processed on the basis of a multifractal model, and the chain-layered topology of the structure is established. The thermal stability of the steroid hormone is studied via thermogravimetric analysis (TGA). It is found that the temperature at which the substance begins to decompose is 480 K. The experimental data are used to calculate standard thermodynamic functions in the region T → 0 to 480 K for the crystalline and liquid states of betamethasone dipropionate.