Stepwise response-guided treatment protocol superior to thrombopoietin receptor agonist-based second-line therapy for severe persistent/chronic immune thrombocytopenia: a multicenter prospective study from China
The stepwise response-guided treatment protocol effectively stratifies children with severe P/CITP based on treatment response, enabling individualized treatment strategies. This protocol achieves comparable efficacy and safety while reducing the treatment burden compared with TPO-RA-based second-line therapy, making it a preferable option for children with severe P/CITP.
Authors
- Runhui Wu (ORCID: https://orcid.org/0000-0003-4030-209X)
- Zhifa Wang (ORCID: https://orcid.org/0000-0001-7363-5101)
- Yu‐Feng Hu (ORCID: https://orcid.org/0000-0001-5715-2070)
- Zhenping Chen (ORCID: https://orcid.org/0000-0002-5273-145X)
- Lingling Fu (ORCID: https://orcid.org/0000-0002-5611-9188)
- Jingyao Ma (ORCID: https://orcid.org/0000-0003-3737-0876)
- Nan Wang (ORCID: https://orcid.org/0009-0005-7049-9980)
- Yan Liu (ORCID: https://orcid.org/0009-0005-9870-6777)
- Lijuan Wang (ORCID: https://orcid.org/0000-0002-6120-6200)
- Jie Ma (ORCID: https://orcid.org/0000-0002-6759-075X)
- Xiaoling Cheng
- Xi Lin (ORCID: https://orcid.org/0009-0000-1299-9008)
Institutions
- Capital Medical University (CN)
- Beijing Children’s Hospital (CN)
Publication Details
- Journal
- Research and Practice in Thrombosis and Haemostasis
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1016/j.rpth.2025.102702
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Beijing Municipal Administration of Hospitals