Hypertriglyceridemia‐modulated gut microbiota promotes lysophosphatidylcholine generation to aggravate acute pancreatitis in a TLR4‐dependent manner
Hypertriglyceridemia (HTG) can lead to the disorder of gut microbiota in mice, resulting in the increase of endotoxin content. HTG can also aggravate the damage of intestinal barrier function and intestinal bacterial translocation in acute pancreatitis (AP) mice. Toll-like receptor 4 gene <i>(Tlr4)</i> knockout can significantly reduce gut permeability and endotoxin invasion in AP mice. In addition, HTG-modulated gut microbiota could up-regulate glycerophospholipid metabolism and increase lysophosphatidylcholine (LysoPC) content in a TLR4-dependent manner, thereby aggravating pancreatic injury in AP.
Authors
- Xiaofan Song
- Jiajing Chang
- Chunlan Xu (ORCID: https://orcid.org/0000-0002-0139-5046)
- Peiyun Liu (ORCID: https://orcid.org/0000-0001-7636-8790)
- Xiaonan Zeng
- Xina Dou
- Lei Qiao (ORCID: https://orcid.org/0000-0003-2907-7629)
- Qinhong Xu (ORCID: https://orcid.org/0000-0003-0654-5290)
- Cheng Wang (ORCID: https://orcid.org/0000-0002-3712-9890)
- Ge Yang (ORCID: https://orcid.org/0000-0002-2624-4412)
- Tianjing Deng
Institutions
- Northwestern Polytechnical University (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
Publication Details
- Journal
- iMeta
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/imt2.70003
- Citations
- 10
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 20.06
Funders
- Northwestern University
- National Natural Science Foundation of China
- Northwestern Polytechnical University