4-1BB agonist targeted to fibroblast activation protein α synergizes with radiotherapy to treat murine breast tumor models
Increased FAP expression in the TME as a result of radiotherapy can be exploited to target agonist 4-1BB immunotherapy to malignant tumor lesions using an FAP-4-1BBL antibody fusion protein.
Authors
- María Collantes (ORCID: https://orcid.org/0000-0003-1162-1470)
- Jon Ander Simón
- Tamara Tanos (ORCID: https://orcid.org/0000-0002-3217-3104)
- Antonio Rullan (ORCID: https://orcid.org/0000-0002-7365-9629)
- Ignacio Melero (ORCID: https://orcid.org/0000-0002-1360-348X)
- Celia Barrio‐Alonso (ORCID: https://orcid.org/0000-0002-2789-1363)
- Carlos Luri‐Rey (ORCID: https://orcid.org/0000-0001-6476-0998)
- Pablo Umaña (ORCID: https://orcid.org/0000-0001-8206-2771)
- Carlos E. de Andrea (ORCID: https://orcid.org/0000-0002-7628-8050)
- Christina Claus (ORCID: https://orcid.org/0000-0001-6316-5855)
- María E. Rodríguez-Ruiz (ORCID: https://orcid.org/0000-0002-9765-2499)
- Álvaro Teijeira (ORCID: https://orcid.org/0000-0002-7339-4464)
- Christian Klein (ORCID: https://orcid.org/0000-0001-7594-7280)
- Eneko Garate-Soraluze (ORCID: https://orcid.org/0000-0002-4071-1427)
- Irantzu Serrano-Mendioroz
- Paloma Sánchez‐Mateos (ORCID: https://orcid.org/0000-0001-6589-4445)
- Leticia Fernández (ORCID: https://orcid.org/0000-0002-3071-8131)
- Claudia Herrero
Institutions
- Roche (Switzerland) (CH)
- Hospital General Universitario Gregorio Marañón (ES)
- University of Oxford (GB)
- Navarre Institute of Health Research (ES)
- Clinica Universidad de Navarra (ES)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
- University College London (GB)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1136/jitc-2024-009852
- Citations
- 13
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 13.59
Funders
- F. Hoffmann-La Roche
- Fundación Científica Asociación Española Contra el Cáncer
- CRIS Cancer Foundation