4-1BB agonist targeted to fibroblast activation protein α synergizes with radiotherapy to treat murine breast tumor models

Increased FAP expression in the TME as a result of radiotherapy can be exploited to target agonist 4-1BB immunotherapy to malignant tumor lesions using an FAP-4-1BBL antibody fusion protein.

Authors

Institutions

Publication Details

Journal
Journal for ImmunoTherapy of Cancer
Published
2025-02-01
DOI
https://doi.org/10.1136/jitc-2024-009852
Citations
13
Primary Topic
Peptidase Inhibition and Analysis
Type
article
Field-Weighted Citation Impact
13.59

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

4-1BB agonist targeted to fibroblast activation protein α synergizes with radiotherapy to treat murine breast tumor models

María Collantes, Jon Ander Simón, Tamara Tanos, Antonio Rullan et al.
13 citations
Journal for ImmunoTherapy of Cancer
Peptidase Inhibition and Analysis
13.59
article

4-1BB agonist targeted to fibroblast activation protein α synergizes with radiotherapy to treat murine breast tumor models

María Collantes, Jon Ander Simón, Tamara Tanos, Antonio Rullan, Ignacio Melero, Celia Barrio‐Alonso, Carlos Luri‐Rey, Pablo Umaña, Carlos E. de Andrea, Christina Claus, María E. Rodríguez-Ruiz, Álvaro Teijeira, Christian Klein, Eneko Garate-Soraluze, Irantzu Serrano-Mendioroz, Paloma Sánchez‐Mateos, Leticia Fernández, Claudia Herrero
article en
13 citations

Abstract

Increased FAP expression in the TME as a result of radiotherapy can be exploited to target agonist 4-1BB immunotherapy to malignant tumor lesions using an FAP-4-1BBL antibody fusion protein.

Journal for ImmunoTherapy of CancerVol. 13(2)
Roche (Switzerland) (CH), Hospital General Universitario Gregorio Marañón (ES), University of Oxford (GB), Navarre Institute of Health Research (ES), Clinica Universidad de Navarra (ES), Centro de Investigación Biomédica en Red de Cáncer (ES), University College London (GB)
F. Hoffmann-La Roche, Fundación Científica Asociación Española Contra el Cáncer, CRIS Cancer Foundation
Good health and well-being
Openalex Percentile: Top 1%
Peptidase Inhibition and Analysis
13.59
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.