CD4 T cell depletion increases memory differentiation of endogenous and CAR T cells and enhances the efficacy of Super2 and IL-33-armored CAR T cells against solid tumors

Unarmored TRP-1-specific or NKG2D CAR T cells have intrinsic stem-like properties and differentiate into memory T cell subsets but are non-protective against primary or secondary tumors. S233 cytokine armoring alone or with CD4 depletion improved effector responses but limited CAR memory T cell generation. S233-armored CAR T cells or CD4 depletion therapy induced endogenous tumor-specific T<sub>CIRC</sub> and T<sub>RM</sub> T cells, but the combination potentiated endogenous memory T cell generation and resulted in improved protection against B16F10 rechallenge.

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Publication Details

Journal
Journal for ImmunoTherapy of Cancer
Published
2025-02-01
DOI
https://doi.org/10.1136/jitc-2024-009994
Citations
6
Primary Topic
CAR-T cell therapy research
Type
article
Field-Weighted Citation Impact
6.27

Funders

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article

CD4 T cell depletion increases memory differentiation of endogenous and CAR T cells and enhances the efficacy of Super2 and IL-33-armored CAR T cells against solid tumors

Haille E. Soderholm, Megen C Wittling, Chrystal Mary Paulos, Alicia M. Santos et al.
6 citations
Journal for ImmunoTherapy of Cancer
CAR-T cell therapy research
6.27
article

CD4 T cell depletion increases memory differentiation of endogenous and CAR T cells and enhances the efficacy of Super2 and IL-33-armored CAR T cells against solid tumors

Haille E. Soderholm, Megen C Wittling, Chrystal Mary Paulos, Alicia M. Santos, Shannon L. Ferry, Mary Jo Turk, Yina H. Huang, Asmaa Mohamed, Michael A. Peck, David Tyler Boone
article en
6 citations

Abstract

Unarmored TRP-1-specific or NKG2D CAR T cells have intrinsic stem-like properties and differentiate into memory T cell subsets but are non-protective against primary or secondary tumors. S233 cytokine armoring alone or with CD4 depletion improved effector responses but limited CAR memory T cell generation. S233-armored CAR T cells or CD4 depletion therapy induced endogenous tumor-specific T<sub>CIRC</sub> and T<sub>RM</sub> T cells, but the combination potentiated endogenous memory T cell generation and resulted in improved protection against B16F10 rechallenge.

Journal for ImmunoTherapy of CancerVol. 13(2)
Dartmouth College (US), Emory University (US), Dartmouth Psychiatric Research Center (US), Winship Cancer Institute, Dartmouth Cancer Center
National Institutes of Health
Good health and well-being
Openalex Percentile: Top 4%
CAR-T cell therapy research
6.27
DOIOpen Access PDFOpenAlex
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CD4 T cell depletion increases memory differentiation of endogenous and CAR T cells and enhances the efficacy of Super2 and IL-33-armored CAR T cells against solid tumors — Haille E. Soderholm, Megen C Wittling, et al. · Journal for ImmunoTherapy of Cancer (2025) | TGRS Research Map | TGRS