Hydrogels Based on Pluronic F127 As Nicotinic Acid and Nicotinamide Delivery Systems

The structural and mechanical properties of hydrogels prepared from Pluronic F127 (20 wt %) are described and analyzed. The effects of nicotinic acid and nicotinamide (1 wt %) additions on the gelation process and the properties of Pluronic hydrogels are considered. The influence of the ionization state of nicotinic acid and nicotinamide molecules on interactions with the polymer matrix of the gel was studied by 1H NMR spectroscopy. A kinetic study of the release and transmembrane transport of nicotinic acid and nicotinamide included in Pluronic hydrogels was performed. The influence of the acidity of the medium on the rate of release of drug compounds from hydrogels and on the transmembrane transfer was analyzed.